"Cov tsis muaj tshuaj lom thiab tsis muaj mob Baking Soda (Sodium Bicarbonate) yog encapsulated nyob rau hauv qhov chaw nyab xeeb nano 'tshuaj ntsiav (liposome), thiab tetracycline nrog cov pob txha-pob quab yuam yog mounted rau saum npoo kom adsorb rau pob txha nto.Thaum osteoclasts rhuav tshem pob txha cov ntaub so ntswg los ntawm kev ua kom muaj kua qaub, lawv tuaj yeem tso Sodium Bicarbonate tam sim ntawd, tiv thaiv cov haujlwm ntawm osteoclasts thiab ua tiav lub hom phiaj ntawm kev tiv thaiv osteoporosis hauv paus. " Ib pab neeg ua haujlwm coj los ntawm Professor Shunwu Ntxuam ntawm Lub Tsev Haujlwm ntawm Orthopedics, Khiav Chaw Kho Mob Shaw Tsev Kho Mob, Zhejiang University, thiab xibfwb Ruikang Tang ntawm Lub Tsev Haujlwm Saib Xyuas Kev Kho Mob, Zhejiang University, tsis ntev los no tau luam tawm lawv cov kev tshawb pom hauv Phau Ntawv Xov Xwm ntawm American Chemical Society.
Raws li cov lus qhia, osteoclasts zoo li tus ntsaum kab-ntoo hauv tsob ntoo, ib zaug ua haujlwm, txawm tias yog tsob ntoo ntau, tab sis kuj vim yog lub sijhawm ntev ntawm qhov lwj thiab lub caij nplooj zeeg. Cov kev tshawb fawb tam sim no ntseeg tias thawj qhov teeb meem txha os yog txawv txav ntawm osteoclasts, thiab acid secretion los ntawm osteoclasts yog suav tias yog thawj qhov tseem ceeb ntawm kev ua kom pob txha los ntawm osteoclasts thiab qhov tsim nyog ua ntej rau lawv degradation ntawm cov pob txha nqaij.
Cov tshuaj tseem ceeb hauv kev kho mob ntawm osteoporosis ua tiav lub hom phiaj los tiv thaiv pob txha resorption thiab txhawb pob txha anabolism los ntawm kev tsom rau cov kev cai ntawm osteoclast lossis osteoblast biology, tab sis lawv tsis tua cov tseem ceeb thawj kauj ruam ntawm sab nraud acid puag ncig ntawm osteoclast tsim los ntawm lub hauv paus. Yog li, cov tshuaj uas twb muaj lawm tuaj yeem ua rau cov pob txha ploj hauv cov neeg laus rau qee yam, tab sis feem ntau tsis tuaj yeem thim rov qab cov pob txha rhuav tshem uas tau tshwm sim, thiab kev xaiv cov tshuaj tsis muaj cov tshuaj tiv thaiv tsis tuaj yeem tuaj yeem ua rau tua-phiaj thiab lwm yam phiv los ntawm cov kabmob.
Ntxiv rau, txawm hais tias osteoclasts yog qhov ua rau txha, ntau txoj kev tshawb fawb tau qhia tias lawv ua lub luag haujlwm txhawb kev tsim pob txha thiab angiogenesis ua "txheej txheem ua ntej" ua ntej tso cov kua qaub. Yog li, nws yog ib qho tseem ceeb heev rau kev ncaj qha rau inhibit osteoclasts.
Pab pawg neeg Shunwu thiab Pab Pawg Tang Ruikang tau tsim kho lub hom phiaj ntawm Sodium Bicarbonate liposomes rau cov pob txha nto, tsim cov txheej txheem alkaline tiv thaiv txheej txheem, neutralizing acid tiv thaiv los ntawm osteoclasts, inhibiting txawv txav ntawm osteoclasts, thiab rov kho qhov sib npaug ntawm cov pob txha microenvironment kom ua tiav cov txiaj ntsig ntawm kev kho pob txha kho Cov.
Lin Xianfeng, tus kws phais neeg mob pob txha ntawm lub tsev kho mob Run Shaw Tsev Kho Mob ntawm Zhejiang University, tau hais tias txoj kev tshawb pom pom tias alkaline liposome cov ntaub ntawv thiab lub chaw acidic ib puag ncig ntawm osteoclasts ua rau ntau cov apoptosis ntawm osteoclasts, thiab ntxiv tawm ntau ntawm cov hlwv tawm. "Nws zoo li txheej txheej ntawm dominoes, uas tau thawb ib txheej zuj zus thiab ntxiv ib kauj ruam zuj zus los tiv thaiv lub pob txha raug mob los ntawm kev txhim kho osteoclasts."
Sijhawm Post: Jan-27-2021