"Cov Baking Soda uas tsis muaj tshuaj lom thiab tsis ua rau mob (Sodium Bicarbonate) raug muab tso rau hauv ib lub nano 'capsule' (liposome) uas muaj kev nyab xeeb, thiab tetracycline nrog lub zog khi pob txha tau teeb tsa rau ntawm qhov chaw kom nqus mus rau qhov chaw ntawm pob txha. Thaum osteoclasts rhuav tshem cov pob txha los ntawm kev tso cov kua qaub, lawv tuaj yeem tso tawm Sodium Bicarbonate tam sim ntawd, tiv thaiv kev ua haujlwm ntawm osteoclasts thiab ua tiav lub hom phiaj ntawm kev tiv thaiv osteoporosis." Ib pab neeg coj los ntawm Xibfwb Shunwu Fan ntawm Lub Tsev Haujlwm Orthopedics, Run Run Shaw Tsev Kho Mob, Zhejiang University, thiab Xibfwb Ruikang Tang ntawm Lub Tsev Haujlwm Chemistry, Zhejiang University, tsis ntev los no tau tshaj tawm lawv cov kev tshawb pom hauv Journal of the American Chemical Society.
Raws li kev qhia, osteoclasts zoo li cov kab ntsaum hauv tsob ntoo, thaum ua haujlwm, txawm tias tsob ntoo siab, tab sis kuj vim yog kev lwj thiab poob mus sij hawm ntev. Cov kev tshawb fawb tam sim no ntseeg tias qhov ua rau mob pob txha yog kev ua haujlwm tsis zoo ntawm osteoclasts, thiab kev tso kua qaub los ntawm osteoclasts yog suav tias yog qhov tseem ceeb pib ntawm kev puas tsuaj ntawm pob txha los ntawm osteoclasts thiab qhov tsim nyog ua ntej rau lawv cov pob txha puas tsuaj.
Cov tshuaj tseem ceeb hauv kev kho mob osteoporosis ua tiav lub hom phiaj ntawm kev tiv thaiv kev rov qab pob txha thiab txhawb kev anabolism pob txha los ntawm kev tsom mus rau kev tswj hwm ntawm osteoclast lossis osteoblast biology, tab sis lawv tsis tua cov kauj ruam tseem ceeb ntawm qhov chaw acid sab nraud ntawm osteoclast tsim los ntawm qhov chaw. Yog li ntawd, cov tshuaj uas twb muaj lawm tuaj yeem ua rau qeeb pob txha poob rau cov neeg laus mus rau qee qhov, tab sis feem ntau tsis tuaj yeem thim rov qab tag nrho qhov kev puas tsuaj pob txha uas tau tshwm sim, thiab kev xaiv cov tshuaj tsis yog pob txha kuj tseem tuaj yeem ua rau tsis yog lub hom phiaj thiab lwm yam kev phiv tshuaj lom ntawm cov kabmob.
Ntxiv mus, txawm hais tias osteoclasts yog cov ua rau mob pob txha, ntau txoj kev tshawb fawb tau qhia tias lawv ua lub luag haujlwm hauv kev txhawb nqa kev tsim pob txha thiab angiogenesis ua "cov hlwb ua ntej" ua ntej tso cov kua qaub. Yog li ntawd, nws yog ib qho tseem ceeb heev uas yuav tsum tiv thaiv osteoclasts kom raug.
Pab neeg ntawm Fan Shunwu thiab pab neeg ntawm Tang Ruikang tau tsim tsa lub hom phiaj ntawm Sodium Bicarbonate liposomes rau ntawm qhov chaw ntawm pob txha, tsim ib txheej tiv thaiv alkaline, neutralizing acid uas osteoclasts tso tawm, tiv thaiv kev ua haujlwm tsis zoo ntawm osteoclasts, thiab rov kho qhov sib npaug ntawm pob txha microenvironment kom ua tiav cov txiaj ntsig ntawm kev kho mob osteoporosis.
Lin Xianfeng, tus kws phais pob txha ntawm Run Run Shaw Tsev Kho Mob ntawm Zhejiang University, tau hais tias kev tshawb fawb pom tias cov khoom siv alkaline liposome thiab qhov chaw acidic ntawm osteoclasts ua rau muaj ntau tus apoptosis ntawm osteoclasts, thiab tso tawm ntau tus extracellular vesicles. "Nws zoo li ib pawg ntawm dominoes, uas raug thawb ib txheej ib zaug thiab nthuav dav ib kauj ruam ib zaug kom tiv taus tag nrho cov pob txha puas tsuaj los ntawm kev txhawb nqa ntawm osteoclasts."
Lub sijhawm tshaj tawm: Lub Ib Hlis-27-2021